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Acknowledgments The authors would like to thank Pat Kornic and the Pernicious Anaemia/B12 Deficiency Support Group and Tracey Witty and the B12 Info group ( Notes Funding There was no funding for this study

In recent years, intranasal (IN) drug delivery has emerged as a promising strategy to bypass the BBB, providing a direct nose-to-brain delivery route via olfactory and trigeminal pathways while minimizing systemic exposure

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